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Human TIGIT Stable CHOK1 Cell Line

Catalog Number CBCL-397
Price Online Inquiry
Unit Quantity 1 x 10^6 cells / 1.0 ml

Introduction

The CHO-K1-TIGIT-Stable Cell Line consists of recombinant CHO-K1 cells that stably overexpress human T cell immunoreceptor with Ig and ITIM domains (TIGIT) on their surface.

Application

Drug screening and biological assays

Background

TIGIT (T cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor expressed on T cells and NK cells. It competes with CD226 for binding to CD155/PVR on target cells, delivering an inhibitory signal that suppresses immune cell activation. TIGIT is upregulated in tumor-infiltrating lymphocytes and contributes to immune evasion in cancer.

Product Information

Category Immune Checkpoint Cell Lines
Cell Line Name CHO-K1-TIGIT-Stable Cell Line
Pharmaceutical Target Immune Molecules
Protein Family T cell immunoreceptor with Ig and ITIM domains family
Gene TIGIT
Species Hamster
Host Cell Line CHOK1
Cell Type Chinese hamster ovary cell line
Morphology Epithelial
Growth Properties Adherent
Selection Marker Puromycin and hygromycin B
Seeding Density Thaw entire contents into an appropriate T25 flask.
Subculture Ratio Recommended a ratio of 1:4-1:8.
Doubling Time Approximately 24 hours
Recommended Medium F12K, 10% FBS, 6 μg/ml Puromycin
Freeze Medium 95% complete growth medium + 5% DMSO
Storage Method Frozen in liquid nitrogen.
Stability Validated for at least 10 passages
QC WB
Mycoplasma Negative
Sterility Testing Negative
Shipping Shipping in dry ice
Biosafety Level BSL-1
Caution For Research Use Only
For research use only. Not for any other purpose.
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