Human TIM3 Stable THP-1 Cell Line

Introduction

THP-1 cell line stable expressing exogenous human TIM3 gene

Application

Drug screening and biological assays

Background

T cell immunoglobulin and mucin-domain containing-3 (TIM-3), also known as Hepatitis A virus cellular receptor 2 (HAVCR2), is a member of TIM family of immune relegating molecules. TIM3 is expressed on multiple activated immune cells including macrophage, monocytes, dendritic cells, Th1, CD8+ T cells and NK cells. Recent studies showed that TIM3 play animportant role as an additional immune checkpoint and a promising drug target for cancer therapy.

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