Jurkat-Human BTLA (Luc)-Reporter Cell
| Catalog Number |
CBCL-0232 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The Human BTLA (Luc) Jurkat Reporter Cell was engineered to express the NFAT response element driving luciferase expression and the full-length human BTLA receptor (Uniprot: Q7Z6A9 1). Co-culture with an anti-human BTLA agonist antibody can result in decreased TCR signaling and NFAT-mediated luminescence.
Application
Screen for anti-human BTLA agonist antibody.
Background
BTLA is an immune checkpoint receptor that inhibits T cell activation and proliferation. It plays a role in maintaining immune tolerance and preventing autoimmune diseases.
Product Information
| Category |
Luciferase Reporter Cell Lines |
| Cell Line Name |
Jurkat-Human BTLA (Luc)-Reporter Cell |
| Protein Family |
B and T lymphocyte attenuator family |
| Gene |
BTLA |
| Species |
Human |
| Host Cell Line |
Jurkat |
| Cell Type |
Human T-cell leukemia |
| Morphology |
Lymphoblastoid |
| Growth Properties |
Suspension |
| Selection Marker |
Puromycin (5 μg/mL) + Hygromycin B (20 μg/mL) |
| Recommended Medium |
RPMI-1640 + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
