Jurkat-Human DR3 (TL1A receptor) (Luc)-Reporter Cell
| Catalog Number | CBCL-0196 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell has been constructed to express the NF-κB signaling response element as well as the human DR3 (TL1A receptor) (Uniprot: Q93038-1). Upon stimulation with human TL1A protein, the TL1A/DR3 interaction induces NF-κB-mediated luminescence. Blocking TL1A binding to DR3 with either anti-TL1A or anti-DR3 antibodies leads to a reduction in luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human TL1A protein.
Background
Death receptor 3 (DR3), also known as TNFRSF25, is a member of the tumor necrosis factor receptor superfamily that binds TNF-like cytokine 1A (TL1A), involved in the regulation of apoptosis and immune responses.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | Jurkat-Human DR3 (TL1A receptor) (Luc)-Reporter Cell |
| Protein Family | Tumor necrosis factor receptor family |
| Gene | DR3 (TL1A receptor) |
| Species | Human |
| Host Cell Line | Jurkat |
| Cell Type | Human T-cell leukemia |
| Morphology | Lymphoblastoid |
| Growth Properties | Suspension |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.