Jurkat-Human DR3 (TL1A receptor) (Luc)-Reporter Cell
| Catalog Number |
CBCL-0235 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell was engineered to express the NF-κB signaling response element and the human DR3 (TL1A receptor) (Uniprot: Q93038-1). Stimulation with human TL1A protein can drive NF-κB-mediated luminescence. Inhibition of TL1A binding to DR3 by either anti-TL1A or anti-DR3 antibodies results in decreased luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human TL1A protein.
Background
DR3 is a tumor necrosis factor receptor superfamily member that binds TL1A and plays a role in regulating immune responses and inflammation.
Product Information
| Category |
Luciferase Reporter Cell Lines |
| Cell Line Name |
Jurkat-Human DR3 (TL1A receptor) (Luc)-Reporter Cell |
| Protein Family |
Tumor necrosis factor receptor family |
| Gene |
DR3 (TL1A receptor) |
| NCBI Gene ID |
8718 |
| Species |
Human |
| Host Cell Line |
Jurkat |
| Cell Type |
Human T-cell leukemia |
| Morphology |
Lymphoblastoid |
| Growth Properties |
Suspension |
| Selection Marker |
Hygromycin B (20 μg/mL) |
| Recommended Medium |
RPMI-1640 + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
