Jurkat-Human DR3 (TL1A receptor) (Luc)-Reporter Cell
| Catalog Number | CBCL-0235 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell was engineered to express the NF-κB signaling response element and the human DR3 (TL1A receptor) (Uniprot: Q93038-1). Stimulation with human TL1A protein can drive NF-κB-mediated luminescence. Inhibition of TL1A binding to DR3 by either anti-TL1A or anti-DR3 antibodies results in decreased luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human TL1A protein.
Background
DR3 is a tumor necrosis factor receptor superfamily member that binds TL1A and plays a role in regulating immune responses and inflammation.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | Jurkat-Human DR3 (TL1A receptor) (Luc)-Reporter Cell |
| Protein Family | Tumor necrosis factor receptor family |
| Gene | DR3 (TL1A receptor) |
| NCBI Gene ID | 8718 |
| Species | Human |
| Host Cell Line | Jurkat |
| Cell Type | Human T-cell leukemia |
| Morphology | Lymphoblastoid |
| Growth Properties | Suspension |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.