Jurkat-Human NKp46 (Luc)-Reporter Cell
| Catalog Number |
CBCL-0587 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The Jurkat-Human NKp46 (Luc)-Reporter Cell is engineered to express the NFAT response element driving luciferase expression systems and the receptor full-length human NKp46 (Uniprot: O76036-1). When co-cultured with anti-human Nkp46 agonist antibody, the interaction of agonist antibody and NKp46 on the surface of Human NKp46 (Luc) Jurkat Reporter Cell results in NFAT-mediated luminescence.
Application
Screen for anti-human NKp46 agonist antibody.
Background
NKp46 (Natural Cytotoxicity Triggering Receptor 1, NCR1) is an activating receptor expressed on NK cells and some innate lymphoid cells. It recognizes viral hemagglutinins and tumor-associated antigens, triggering cytotoxicity and cytokine production. NKp47 is critical for NK cell-mediated antiviral and antitumor immunity.
Product Information
| Category |
Immune Checkpoint Cell Lines |
| Cell Line Name |
Jurkat-Human NKp46 (Luc)-Reporter Cell |
| Protein Family |
Natural killer cell protein family |
| Gene |
NKp46 |
| Species |
Human |
| Host Cell Line |
Jurkat |
| Cell Type |
Human T-cell leukemia |
| Morphology |
Lymphoblastoid |
| Growth Properties |
Suspension |
| Selection Marker |
Puromycin (5 μg/mL) + Hygromycin B (20 μg/mL) |
| Recommended Medium |
RPMI-1640 + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
