Jurkat-NFAT-Luc2-ACEII-CD3zeta-Reporter Cell Line
| Catalog Number | CBCL-0283 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
This stable Jurkat cell line expresses exogenous human ACEII, CD3zeta, and luciferase under the control of the NFAT signaling pathway, enabling studies of immune receptor signaling and NFAT-dependent gene expression.
Application
Drug screening and biological assays
Background
ACE2 (Angiotensin-converting enzyme 2) is a key enzyme in the renin-angiotensin system (RAS) and serves as the receptor for the SARS-CoV-2 virus, which causes COVID-19. ACE2 is widely expressed in various tissues, including the lungs, heart, kidneys, and intestines, and plays a crucial role in regulating blood pressure and fluid balance. CD3-zeta (CD3Z) is a component of the T cell receptor (TCR) complex and is essential for TCR signaling and T cell activation. Mutations in the CD3Z gene can lead to immunodeficiency disorders characterized by recurrent infections and impaired T cell function.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | Jurkat-NFAT-Luc2-ACEII-CD3zeta-Reporter Cell Line |
| Protein Family | Angiotensin converting enzyme family; T cell surface glycoprotein family |
| Gene | ACEII; CD3-zeta |
| Species | Human |
| Host Cell Line | Jurkat |
| Cell Type | Human T-cell leukemia |
| Morphology | Lymphoblastoid |
| Growth Properties | Suspension |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |