Jurkat-NFAT-luc2-B2M-KO-1A4-Stable Cell Line

Introduction

This stable Jurkat cell line with a B2M gene knockout expresses exogenous luciferase under the control of the NFAT signaling pathway, enabling studies of NFAT-dependent gene expression in the absence of B2M.

Application

Drug screening and biological assays

Background

Beta-2-microglobulin (B2M) is a component of major histocompatibility complex (MHC) class I molecules, which are essential for antigen presentation to CD8+ T cells. B2M is a small protein that associates with the alpha chain of MHC class I molecules to form a stable complex on the cell surface. This complex presents endogenous antigens to CD8+ T cells, initiating an immune response against infected or cancerous cells. B2M is widely expressed in all nucleated cells and plays a critical role in the immune system. Mutations in the B2M gene can lead to MHC class I deficiency, impairing antigen presentation and increasing susceptibility to infections and cancer.

Product Information