MC38-PD1-LAG3-Stable Cell Line
| Catalog Number |
CBCL-0407 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
The MC38-PD1-LAG3-Stable Cell Line is a stable clone of the MC38 cell line that expresses the exogenous PD1 and LAG3 genes.
Application
Drug screening and biological assays
Background
PD-1 (Programmed Death-1) is an immune checkpoint receptor expressed on activated T-cells. It binds to its ligands PD-L1 and PD-L2, inhibiting T-cell activation and promoting immune tolerance, which is exploited by tumors to evade immune surveillance.
Product Information
| Category |
Immune Molecules Cell Lines |
| Cell Line Name |
MC38-PD1-LAG3-Stable Cell Line |
| Protein Family |
Programmed cell death protein 1 family; Lymphocyte activation gene-3 family |
| Gene |
PD1; LAG3 |
| NCBI Gene ID |
PD1（PDCD1）：5133；LAG3：3902 |
| Species |
Mouse |
| Host Cell Line |
MC38 |
| Cell Type |
Mouse colorectal carcinoma |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Puromycin |
| Recommended Medium |
RPMI1640+10%FBS+5µg/mL Puromycin |
| Freeze Medium |
70% RPMI1640+20% FBS+10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
