MKN45-CLDN18.2-PDL1-Stable Cell Line
| Catalog Number |
CBCL-0423 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
The MKN45-CLDN18.2-PDL1-Stable Cell Line is a stable clone of the MKN45 cell line that expresses the exogenous CLDN18.2 and PDL1 genes.
Application
Drug screening and biological assays
Background
CLDN18.2 is a splice variant of claudin 18, expressed on gastric and pancreatic cancer cells; PDL1 is programmed death-ligand 1, an immune checkpoint ligand. Co-targeting CLDN18.2 and PDL1 may enhance antitumor immunity.
Product Information
| Category |
Immune Molecules Cell Lines |
| Cell Line Name |
MKN45-CLDN18.2-PDL1-Stable Cell Line |
| Protein Family |
Claudin family; Programmed cell death ligand 1 family |
| Gene |
CLDN18.2; PDL1 |
| NCBI Gene ID |
CLDN18：51208 ；PDL1：29126 |
| Species |
Human |
| Host Cell Line |
MKN45 |
| Cell Type |
Human gastric cancer cell line |
| Morphology |
Epithelial-like |
| Growth Properties |
Adherent |
| Selection Marker |
Puromycin |
| Recommended Medium |
RPMI1640+10%FBS+1µg/ml Puromycin+300µg/ml Hygromycin B |
| Freeze Medium |
70% RPMI1640+20% FBS+10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
