NF-kb Luciferase Reporter Stable HT1080 Cell Line

Introduction

HT1080 cell line stable expressing exogenous luciferase gene under the control of NFkb responsive element

Application

Drug screening and biological assays

Background

NFkB pathway plays an important role in controlling many biological processes including transcription of DNA, cytokine production, cell survival, immune responses to infection, developmental processes, synaptic plasticity, memory and cancer development. In response to the various stimuli, NFkB pathway is activated and NFKB protein complex translocate from cytoplasm to nucleus, regulates a wide spectrum of gene expression after binds to its response element on the promoter region of downstream gene.

Product Information