Background
NRAS is a GTP binding enzyme, belonging to Ras gene family, plays an important role in the regulation of cell proliferation, the overactivation due to mutation can lead to continuously cell proliferation, and eventually develop into cancer.
Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly popular as a model system for assessing both the potency and downstream signaling of kinase oncogenes, and the ability of small-molecule kinase inhibitors to block kinase activity.
