Raji-Human CD155-Stable Cell Line
| Catalog Number | CBCL-0575 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Raji-Human CD155-Stable Cell Line is engineered to express full-length human CD155 (Uniprot: P15151-1), used to mimic cancer target cells. When co-cultured with human TIGIT Reporter Cell, the TIGIT/CD155 interaction inhibits TCR signaling and NFAT-mediated luminescence. Blocking the TIGIT/CD155 interaction by either anti-TIGIT or anti-CD155 antibodies releases the inhibitory signal and results in TCR activation and NFAT-mediated luminescence.
Application
Useful for cell-based CD155 binding assay
Background
CD155 (PVR, Poliovirus Receptor) is a transmembrane protein expressed on epithelial cells and tumor cells. It binds to DNAM-1 (activating) and TIGIT/CD96 (inhibitory) receptors on immune cells, modulating cytotoxicity and immune escape. Overexpression correlates with poor cancer prognosis.
Product Information
| Category | Immune Checkpoint Cell Lines |
| Cell Line Name | Raji-Human CD155-Stable Cell Line |
| Protein Family | Nectin family |
| Gene | CD155 |
| NCBI Gene ID | 5817 |
| Species | Human |
| Host Cell Line | Raji |
| Cell Type | Human B-cell lymphoma |
| Morphology | Lymphoblastoid |
| Growth Properties | Suspension |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |