T47D-Estrogen Luciferase Reporter-Stable Cell Line
| Catalog Number |
CBCL-0738 |
| Price |
Online Inquiry |
| Unit Quantity |
2 x 10^6 cells / 1.0 ml |
Introduction
The T47D-Estrogen Luciferase Reporter-Stable Cell Line is a human breast cancer cell line that monitors the activity of the ER signaling pathway through a Firefly luciferase reporter under the control of an estrogen response element (ERE). This cell line has been validated in assays involving the inhibition of 17β-Estradiol-induced reporter activation by ER antagonists.
Application
Drug screening and biological assays
Background
ESR1 (Estrogen Receptor 1) is a nuclear receptor that binds estrogens. It regulates the transcription of target genes involved in various physiological processes such as reproductive development, bone metabolism, and cardiovascular function. Dysregulation of ESR1 is associated with breast cancer and other diseases.
Product Information
| Category |
Cell Signaling Cell Lines |
| Cell Line Name |
T47D-Estrogen Luciferase Reporter-Stable Cell Line |
| Protein Family |
Estrogen receptor family |
| Gene |
Estrogen |
| NCBI Gene ID |
2099 |
| Species |
Human |
| Host Cell Line |
T47D |
| Cell Type |
Human breast cancer |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
RPMI-1640 medium + 10% FBS |
| Freeze Medium |
90% FBS + 10% DMSO |
| Storage Method |
Liquid Nitrogen |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
